ISOLATION AND STRUCTURE DETERMINATION OF NATURAL ANALOGS OF THE MYCOTOXIN OCHRATOXIN-A PRODUCED BY ASPERGILLUS-OCHRACEUS

被引：21

作者：

HADIDANE, R

BACHA, H

CREPPY, EE

HAMMAMI, M

ELLOUZE, F

DIRHEIMER, G

机构：

[1] UNIV BORDEAUX 2,TOXICOL & HYG APPL LAB,3 TER PL VICTOIRE,F-33076 BORDEAUX,FRANCE

[2] UNIV CTR MONASTIR,FAC MED DENT,MONASTIR 5000,TUNISIA

[3] UNIV BORDEAUX 2,FAC MED,F-33076 BORDEAUX,FRANCE

[4] UNIV BORDEAUX 2,FAC PHARM,F-33076 BORDEAUX,FRANCE

[5] UNIV STRASBOURG 1,CNRS,INST BIOL MOLEC & CELLULAIRE,F-67084 STRASBOURG,FRANCE

[6] UNIV STRASBOURG 1,CTR RECH,F-67084 STRASBOURG,FRANCE

来源：

TOXICOLOGY | 1992年 / 76卷 / 03期

关键词：

OCHRATOXIN-A; OCHRATOXIN-A ANALOGS; SERINE-OCHRATOXIN; HYDROXYPROLINE-OCHRATOXIN; LYSINE-OCHRATOXIN;

D O I：

10.1016/0300-483X(92)90192-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisation of both their amino acid moieties and of ochratoxin alpha, the chlorinated dihydroisocoumarin moiety of ochratoxin A. These structures were confirmed by mass spectrum analysis.

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页码：233 / 243

页数：11

相关论文

共 31 条

[1] ISOLATION AND PURIFICATION OF OCHRATOXIN-A [J].

BUNGE, I ;

HELLER, K ;

ROSCHENTHALER, R .

ZEITSCHRIFT FUR LEBENSMITTEL-UNTERSUCHUNG UND-FORSCHUNG, 1979, 168 (06) :457-458

[2] INVIVO AND INVITRO INHIBITION OF PROTEIN-SYNTHESIS IN BACILLUS-STEAROTHERMOPHILUS BY OCHRATOXIN-A [J].

BUNGE, I ;

DIRHEIMER, G ;

ROSCHENTHALER, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (02) :398-405

[3]

Ceovic S, 1976, Lijec Vjesn, V98, P301

[4] GEOGRAPHIC CORRELATION BETWEEN OCCURRENCE OF ENDEMIC NEPHROPATHY AND URINARY-TRACT TUMORS IN VRATZA DISTRICT, BULGARIA [J].

CHERNOZEMSKY, IN ;

STOYANOV, IS ;

PETKOVABOCHAROVA, TK ;

NICOLOV, IG ;

DRAGANOV, IV ;

STOICHEV, II ;

TANCHEV, Y ;

NAIDENOV, D ;

KALCHEVA, ND .

INTERNATIONAL JOURNAL OF CANCER, 1977, 19 (01) :1-11

[5] INVITRO INHIBITION OF YEAST VALYL-TRNA SYNTHETASE BY THE VALINE HOMOLOG OF OCHRATOXIN-A [J].

CREPPY, EE ;

MAYER, M ;

KERN, D ;

SCHLEGEL, M ;

STEYN, PS ;

VLEGGAAR, R ;

DIRHEIMER, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 656 (02) :265-268

[6] COMPARATIVE-STUDY OF THE EFFECT OF OCHRATOXIN A ANALOGS ON YEAST AMINOACYL-TRANSFER RNA-SYNTHETASES AND ON THE GROWTH AND PROTEIN-SYNTHESIS OF HEPATOMA-CELLS [J].

CREPPY, EE ;

KERN, D ;

STEYN, PS ;

VLEGGAAR, R ;

ROSCHENTHALER, R ;

DIRHEIMER, G .

TOXICOLOGY LETTERS, 1983, 19 (03) :217-224

[7] INHIBITION OF PROTEIN-SYNTHESIS IN MICE BY OCHRATOXIN-A AND ITS PREVENTION BY PHENYLALANINE [J].

CREPPY, EE ;

ROSCHENTHALER, R ;

DIRHEIMER, G .

FOOD AND CHEMICAL TOXICOLOGY, 1984, 22 (11) :883-886

[8] COMBINED ACTION OF CITRININ AND OCHRATOXIN-A ON HEPATOMA TISSUE-CULTURE CELLS [J].

CREPPY, EE ;

LORKOWSKI, G ;

BECK, G ;

ROSCHENTHALER, R ;

DIRHEIMER, G .

TOXICOLOGY LETTERS, 1980, 5 (06) :375-380

[9] ACTION OF OCHRATOXIN A ON CULTURED HEPATOMA-CELLS - REVERSION OF INHIBITION BY PHENYLALANINE [J].

CREPPY, EE ;

LUGNIER, AAJ ;

BECK, G ;

ROSCHENTHALER, R ;

DIRHEIMER, G .

FEBS LETTERS, 1979, 104 (02) :287-290

[10]

CREPPY EE, 1979, CHEM-BIOL INTERACT, V17, P329

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