AGE-DEPENDENT AND SEX-DEPENDENT CHANGE IN STRATUM-CORNEUM SPHINGOLIPIDS

被引：70

作者：

DENDA, M ^{[1
]}

KOYAMA, J ^{[1
]}

HORI, J ^{[1
]}

HORII, I ^{[1
]}

TAKAHASHI, M ^{[1
]}

HARA, M ^{[1
]}

TAGAMI, H ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT DERMATOL,SENDAI,MIYAGI 980,JAPAN

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1993年 / 285卷 / 07期

关键词：

SPHINGOLIPIDS; CERAMIDES; AGING;

D O I：

10.1007/BF00372135

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We measured six stratum corneum sphingolipid species (ceramides 1-6) in 26 males and 27 females, and found a significant change in their percentage composition only among female subjects of different age groups. There was a significant increase in ceramide 1 and 2 with a corresponding decrease in ceramide 3 and 6 from prepubertal age to adulthood. Thereafter the ratio of ceramide 2 to total sphingolipids decreased with age in contrast to ceramide 3 which showed an increase. Such a pattern of change in the aging population is different from that observed in scaly skin experimentally induced by tape stripping. The present results suggest a significant influence of female hormones on the composition of stratum corneum sphingolipids. Moreover, the different patterns of change in sphingolipid composition of stratum corneum lipids between scales from inflammatory skin and those from aged skin also suggest that epidermal biosynthesis of sphingolipids is influenced by epidermal proliferative activity.

引用

页码：415 / 417

页数：3

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