SEPARATION OF DIFFERENT INTERICTAL DISCHARGE PATTERNS IN ACUTE EXPERIMENTALLY-INDUCED EPILEPTIC FOCI OF THE RAT IN-VIVO

被引：13

作者：

DORN, T ^{[1
]}

WITTE, OW ^{[1
]}

机构：

[1] UNIV DUSSELDORF,NEUROL KLIN,MOORENSTR 5,W-4000 DUSSELDORF 1,GERMANY

来源：

BRAIN RESEARCH | 1993年 / 616卷 / 1-2期

关键词：

EXPERIMENTAL EPILEPSY; EPILEPTIC FOCUS; INTERICTAL SPIKE; DISCHARGE PATTERN; PENICILLIN; EEG;

D O I：

10.1016/0006-8993(93)90221-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular I/s1 discharges, patterns with irregular discharges of about 0.5/s1 as well as compound patterns comprising discharges with intervals of about 300 ms could be differentiated by means of interval histograms and autocorrelation functions. These patterns occurred in an ordered sequence indicating that the different rhythms are activated by a progressive enlargement of the focus and duration of focal activity. The experiments suggest that different interictal discharge patterns can occur within the same brain regions and are not specific for a certain etiology; instead they seem to represent 'resonance' frequencies characteristic for the brain tissue which are disclosed under pathophysiological conditions.

引用

页码：303 / 306

页数：4

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