EVIDENCE FOR NITRIC OXIDE-MEDIATED OXIDATIVE DAMAGE IN CHRONIC INFLAMMATION - NITROTYROSINE IN SERUM AND SYNOVIAL-FLUID FROM RHEUMATOID PATIENTS

被引：620

作者：

KAUR, H

HALLIWELL, B

机构：

[1] Pharmacology Group, King's College, London, SW3 6LX, Manresa Road

来源：

FEBS LETTERS | 1994年 / 350卷 / 01期

关键词：

PEROXYNITRITE; NITRIC OXIDE; NITROTYROSINE; OXIDATIVE DAMAGE; RHEUMATOID ARTHRITIS;

D O I：

10.1016/0014-5793(94)00722-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of nitric oxide (NO.) with superoxide radical generates peroxynitrite, which can decompose to products that nitrate aromatic amino acids. Such nitro-aromatics may be 'markers' of NO.-dependent oxidative damage. Blood serum and synovial fluid from patients with the inflammatory joint disease rheumatoid arthritis contain 3-nitrotyrosine, By contrast, body fluids from normal subjects and patients with osteoarthritis contain no detectable 3-nitrotyrosine; much lower levels were found in serum from patients in the early stages of rheumatoid arthritis. This is evidence that NO. plays a role in joint damage in rheumatoid arthritis.

引用

收藏

页码：9 / 12

页数：4

相关论文

共 17 条

[1] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[2]

BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229

[3] INCREASED CONCENTRATIONS OF NITRITE IN SYNOVIAL-FLUID AND SERUM SAMPLES SUGGEST INCREASED NITRIC-OXIDE SYNTHESIS IN RHEUMATIC DISEASES [J].

FARRELL, AJ ;

BLAKE, DR ;

PALMER, RMJ ;

MONCADA, S .

ANNALS OF THE RHEUMATIC DISEASES, 1992, 51 (11) :1219-1222

[4]

HALLIWELL B, 1992, J LAB CLIN MED, V119, P598

[5] NITRIC-OXIDE - A CYTO-TOXIC ACTIVATED MACROPHAGE EFFECTOR MOLECULE [J].

HIBBS, JB ;

TAINTOR, RR ;

VAVRIN, Z ;

RACHLIN, EM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) :87-94

[6] THE REACTION OF NO WITH SUPEROXIDE [J].

HUIE, RE ;

PADMAJA, S .

FREE RADICAL RESEARCH COMMUNICATIONS, 1993, 18 (04) :195-199

[7] PEROXYNITRITE-MEDIATED TYROSINE NITRATION CATALYZED BY SUPEROXIDE-DISMUTASE [J].

ISCHIROPOULOS, H ;

ZHU, L ;

CHEN, J ;

TSAI, M ;

MARTIN, JC ;

SMITH, CD ;

BECKMAN, JS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) :431-437

[8] PEROXYNITRITE, A CLOAKED OXIDANT FORMED BY NITRIC-OXIDE AND SUPEROXIDE [J].

KOPPENOL, WH ;

MORENO, JJ ;

PRYOR, WA ;

ISCHIROPOULOS, H ;

BECKMAN, JS .

CHEMICAL RESEARCH IN TOXICOLOGY, 1992, 5 (06) :834-842

[9] SUPPRESSION OF ARTHRITIS BY AN INHIBITOR OF NITRIC-OXIDE SYNTHASE [J].

MCCARTNEYFRANCIS, N ;

ALLEN, JB ;

MIZEL, DE ;

ALBINA, JE ;

XIE, QW ;

NATHAN, CF ;

WAHL, SM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :749-754

[10] OXYGEN FREE-RADICALS, INFLAMMATION, AND SYNOVITIS - THE CURRENT STATUS [J].

MERRY, P ;

WINYARD, PG ;

MORRIS, CJ ;

GROOTVELD, M ;

BLAKE, DR .

ANNALS OF THE RHEUMATIC DISEASES, 1989, 48 (10) :864-870