LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13

被引：1489

作者：

WOOSTER, R

NEUHAUSEN, SL

MANGION, J

QUIRK, Y

FORD, D

COLLINS, N

NGUYEN, K

SEAL, S

TRAN, T

AVERILL, D

FIELDS, P

MARSHALL, G

NAROD, S

LENOIR, GM

LYNCH, H

FEUNTEUN, J

DEVILEE, P

CORNELISSE, CJ

MENKO, FH

DALY, PA

ORMISTON, W

MCMANUS, R

PYE, C

LEWIS, CM

CANNONALBRIGHT, LA

PETO, J

PONDER, BAJ

SKOLNICK, MH

EASTON, DF

GOLDGAR, DE

STRATTON, MR

机构：

[1] INST CANC RES, EPIDEMIOL SECT, SUTTON SM2 5NG, SURREY, ENGLAND

[2] INST CANC RES, MOLEC CARCINOGENESIS SECT, SUTTON SM2 5NG, SURREY, ENGLAND

[3] MCGILL UNIV, DIV HUMAN GENET, MONTREAL H3G 1A4, PQ, CANADA

[4] MCGILL UNIV, DEPT MED, DIV MED GENET, MONTREAL H3G 1A4, PQ, CANADA

[5] CREIGHTON UNIV, SCH MED, DEPT PREVENT MED & PUBL HLTH, OMAHA, NE 68178 USA

[6] INT AGCY RES CANC, F-69372 LYON 08, FRANCE

[7] INST GUSTAVE ROUSSY, VILLEJUIF, FRANCE

[8] LEIDEN UNIV, DEPT PATHOL, 2333 AL LEIDEN, NETHERLANDS

[9] LEIDEN UNIV, DEPT HUMAN GENET, 2333 AL LEIDEN, NETHERLANDS

[10] FREE UNIV AMSTERDAM, DEPT CLIN GENET, 1007 MB AMSTERDAM, NETHERLANDS

[11] UNIV IRELAND TRINITY COLL, ST JAMES HOSP, SCH MED, DEPT MED, DUBLIN 8, IRELAND

[12] UNIV CAMBRIDGE, DEPT PATHOL, CRC, HUMAN CANC GENET GRP, CAMBRIDGE CB2 1QP, ENGLAND

[13] UNIV UTAH, DEPT INTERNAL MED, SALT LAKE CITY, UT 84132 USA

来源：

SCIENCE | 1994年 / 265卷 / 5181期

关键词：

D O I：

10.1126/science.8091231

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A small proportion oi breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

引用

页码：2088 / 2090

页数：3

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