VENTRAL MEDULLARY SURFACE RESPONSES TO HYPOXIC AND HYPEROXIC TRANSIENT VENTILATORY CHALLENGES IN THE CAT

被引：5

作者：

ALJADEFF, G

GOZAL, D

CARROLL, JL

RECTOR, DM

HARPER, RM

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90095

[2] UNIV SO CALIF,CHILDRENS HOSP,SCH MED,DIV NEONAT & PED PULMONOL,LOS ANGELES,CA 90027

[3] JOHNS HOPKINS UNIV,SCH MED,DIV PED PULMONOL,BALTIMORE,MD

来源：

LIFE SCIENCES | 1995年 / 57卷 / 04期

关键词：

OPTICAL IMAGINING; VENTRAL MEDULLARY SURFACE; CAROTID BODY; RESPIRATION;

D O I：

10.1016/0024-3205(95)00290-M

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Carotid body afferent contributions to activity of the intermediate area of the ventral medullary surface (IVMS) following transient hypoxia and hyperoxia were examined in 6 spontaneously breathing, pentobarbital-anesthetized cats. Two tidal breaths of 100% N-2, 100% O-2, or room air, were randomly administered before and after carotid sinus denervation (CSD). Images of scattered light from the IVMS showed that activity increased with hypoxia (10.1 +/- 2.4%), and decreased with hyperoxia (4.8 +/- 1.8%). CSD significantly increased the magnitude and delayed the onset of the hypoxic response, but reversed the initial component of the hyperoxic response. We conclude that carotid body afferents modulate the magnitude and timing of IVMS responses to transient respiratory challenges.

引用

页码：319 / 324

页数：6

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