EFFECT OF MARIHUANA EXTRACT ON FETAL HAMSTERS AND RABBITS

被引：78

作者：

GEBER, WF

SCHRAMM, LC

机构：

[1] Department of Pharmacology, Medical College of Georgia, Augusta

[2] Department of Pharmacognosy, School of Pharmacy, University of Georgia, Athens

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1969年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0041-008X(69)90108-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Malformations of the brain, spinal cord, foreleg, and liver as well as edema of the head and spinal region were found in fetal hamsters and rabbits from mothers injected subcutaneously with multiple doses of marihuana extract (resin) from crude plant material grown in either New Jersey or Mexico. Pregnant hamsters received a total of 25-300 mg/kg of extract during days 6 through 8 of gestation. Pregnant rabbits received a total of 130-500 mg/kg of extract during days 7 through 10 of gestation. The extracts were embryocidal and increased the number of runts in the fetal rabbits. The extracts were not embryocidal toward the fetal hamster but did increase the proportion of runts found to greater than the control percentage. © 1969.

引用

页码：276 / &

共 23 条

[1] LSD - INJECTION EARLY IN PREGNANCY PRODUCES ABNORMALITIES IN OFFSPRING OF RATS [J].