SELECTIVE ACID-CATALYZED HYDROLYSES OF METHOXYSULFANILAMIDODIAZINES

被引：11

作者：

VENTURELLA, VS

机构：

[1] Temple University School of Pharmacy, Philadelphia, Pennsylvania

[2] Hoffmann-La Roche Inc., Nutley, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 07期

关键词：

Hydrolyses—acid catalyzed; IR spectrophotometry—structure; Methoxysulfanilamidodiazines—hydrolyses; TLC—identity; UV spectrophotometry—structure;

D O I：

10.1002/jps.2600570713

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dilute acid hydrolysis of 3‐methoxy‐6‐sulfanilamidopyridazine and several methoxysulfanilamidopyrimidines has been studied. Experiments show that in cases where an intermediate 2‐pyrimidone is a possible postulation, further hydrolysis usually leads to the formation of sulfanilamide and the corresponding hydroxypyrimidine. A multistage route for the acidic degradation of 3‐methoxy‐6‐sulfanilamidopyridazine, 2,4‐dimethoxy‐6‐sulfanilamidopyrimidine, and 2‐methylthio‐4‐methoxy‐6‐sulfanilamidopyrimidine is proposed. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1151 / +

页数：1

共 28 条

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