STIMULATION OF DNA SYNTHESIS IN CULTURES OF MOUSE SPLEEN CELL SUSPENSIONS BY BOVINE TRANSFERRIN

被引：63

作者：

VOGT, A

MISHELL, RI

DUTTON, RW

机构：

[1] Hygiene-Institut der Universität, Freiburg i. Br.

[2] Scripps Clinic, Research Foundation, La Jolla, CA 92037

来源：

EXPERIMENTAL CELL RESEARCH | 1969年 / 54卷 / 02期

关键词：

D O I：

10.1016/0014-4827(69)90232-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Marked enhancement of DNA synthesis was observed in spleen cell suspensions of normal B6D2F1 mice cultured in the presence of fetal bovine serum. Nearly all of the stimulatory potency of the fetal bovine serum was found to be related to the transferrin fraction. Bovine transferrin isolated from ox serum, which itself did not possess any stimulatory activity, caused enhancement of thymidine incorporation to the same extent as fetal bovine transferrin. No immunological mechanism seems to be involved in the action of bovine transferrin on lymphoid cells, as cells obtained from mice unresponsive to bovine transferrin responded to the same degree as cells derived from normal or sensitized animals. © 1969.

引用

页码：195 / &

共 14 条

[1]

BAIN B, 1963, FED PROC, V22, P428

[2] DISC ELECTROPHORESIS .2. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS [J].