COMPARATIVE STUDIES ON IMMUNOLOGICALLY AND NON-IMMUNOLOGICALLY PRODUCED SLOW-REACTING SUBSTANCES FROM MAN, GUINEA-PIG AND RAT

被引：32

作者：

MORRIS, HR ^{[1
]}

PIPER, PJ ^{[1
]}

TAYLOR, GW ^{[1
]}

TIPPINS, JR ^{[1
]}

机构：

[1] ROYAL COLL SURG ENGLAND,DEPT PHARMACOL,LONDON WC2A 3PN,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 67卷 / 02期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb08664.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Slow‐reacting substance of anaphylaxis (SRS‐A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea‐pig lung. A slow‐reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187. These substances were extensively purified by charcoal adsorption, Sephadex G‐15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. The three substances are pharmacologically, chemically and chromatographically indistinguishable. Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis. 1979 British Pharmacological Society

引用

页码：179 / 184

页数：6

共 13 条

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