MECHANISMS OF INCREASED MAXIMUM EXPIRATORY FLOW DURING HEO2 BREATHING IN DOGS

The authors used the retrograde-catheter technique to investigate the effect of a helium-oxygen gas mixture (HeO2) on resistance to maximum expiratory flow (Vmax) in airways subsegments between alveoli and the equal pressure point (EPP), and between EPP and the flow-limiting segment (FLS). FLS were found at the same site in main-stem bronchi on both air and HeO2 in most dogs studied. Static elastic recoil pressure (Pel = 7 ± 1 cmH2O) and the lateral pressure at FLS (Ptm' = 11 ± 3 cmH2O) were not different on the two gases, and ΔVmax averaged 33 ± 12%, EPP were located on HeO2 in segmental bronchi (7 ± 2 mm ID), and EPP on air were always located more downstream. There was no density dependence of resistance between alveoli and EPP on HeO2, and ΔVmax was due to the marked density dependence of the pressure losses of convective acceleration in the short airway segment between EPP HeO2 and FLS. Assuming that FLS is the 'choke point', these findings are consistent with wave-speed theory of flow limitation modified to account for viscous pressure losses in peripheral airways. These results and conclusions question previous interpretations of ΔVmax as an index of peripheral airways obstruction, and demonstrate the utility of wave-speed theory in explaining complicated mechanisms of expiratory flow limitation.