GLOMERULAR FUNCTION AND MICROALBUMINURIA IN CHILDREN WITH INSULIN-DEPENDENT DIABETES

被引：15

作者：

LABORDE, K

LEVYMARCHAL, C

KINDERMANS, C

DECHAUX, M

CZERNICHOW, P

SACHS, C

机构：

[1] Department of Physiology, Hôpital Necker-enfants Malades, Paris Cedex 15, F-75730

[2] Department of Paediatric Endocrinology and Diabetes, Hôpital Necker-Enfants Malades, Paris Cedex 15, F-75730

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 01期

关键词：

Diabetic nephropathy; Metabolic control; Microalbuminuria; Renal haemodynamics;

D O I：

10.1007/BF00858437

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Renal function has been evaluated in 45 diabetic children (age 12.5±4 years) with a mean diabetes duration of 4.9±3.5 years. Glomerular filtration rate (GFR; inulin and creatinine clearances), renal plasma flow (RPF; PAH clearance), resting urinary albumin excretion (UAE) were measured and compared with indexes of metabolic control: Hb A1C and blood glucose values (mean, post-prandial and maximal excursion) on the same day. GFR (inulin clearance) and RPF were significantly increased in the diabetic group (171±31 and 778±172 ml/min per 1.73 m2) compared with controls (124±18 and 631±128 ml/min per 1.73 m2). Both parameters were strongly correlated (r=0.73;P<0.001). Creatinine clearance was not correlated to inulin clearance. Hyperfiltration (inulin clearance above 160 ml/min per 1.73 m2) was noted in 61% of the patients and was independent of diabetes duration. Five diabetic children had a UAE level above 15 μg/min. No relationship could be established between UAE and any of the metabolic indexes; GFR was weakly correlated to HbA1C (r=0.35;P<0.05), to mean (r=0.35;P<0.05) and post-prandial blood glucose (r=0.37;P<0.05). In contrast, there was a strong correlation between GFR and the maximal blood excursion (r=0.62;P<0.001). The study shows that renal abnormalities can be detected with a high frequency in diabetic subjects characterized by both an early onset and a short duration of diabetes and suggests the need for a more systematic evaluation of renal parameters in this population. © 1990 IPNA.

引用

页码：39 / 43

页数：5

共 20 条

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