LOCALIZATION OF SPECIFICITY DETERMINING SITES IN CADHERIN CELL-ADHESION MOLECULES

被引:428
作者
NOSE, A
TSUJI, K
TAKEICHI, M
机构
[1] Department of Biophysics Faculty, Science Kyoto University Kitashirakawa, 606, Sakyo-ku Kyoto
关键词
D O I
10.1016/0092-8674(90)90222-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesive selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The results showed that the amino-terminal 113 amino acid region is essential to determine the specificities, and within this region we could identify especially important sites in which amino acid substitutions altered the binding specificity of cadherins. We also found that the epitopes for antibodies capable of blocking cadherin action are located in this amino-terminal region. © 1990.
引用
收藏
页码:147 / 155
页数:9
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