RECOMBINANT INTERLEUKIN-4 ENHANCES THE CHEMILUMINESCENT OXIDATIVE BURST OF MURINE PERITONEAL-MACROPHAGES

被引：11

作者：

TAN, HP

NEHLSENCANNARELLA, SL

GARBEROGLIO, CA

TOSK, JM

机构：

[1] JERRY L PETTIS MEM VET ADM MED CTR, PSYCHIAT SERV, NEUROIMMUNOL LAB, 116A, LOMA LINDA, CA 92357 USA

[2] LOMA LINDA UNIV, SCH MED, CTR IMMUNOL, LOMA LINDA, CA 92354 USA

[3] LOMA LINDA UNIV, SCH MED, DEPT MICROBIOL, LOMA LINDA, CA 92354 USA

[4] LOMA LINDA UNIV, SCH MED, DEPT SURG, LOMA LINDA, CA 92354 USA

[5] LOMA LINDA UNIV, SCH MED, DEPT PATHOL, LOMA LINDA, CA 92354 USA

[6] LOMA LINDA UNIV, SCH MED, DEPT PSYCHIAT, LOMA LINDA, CA 92354 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1991年 / 49卷 / 06期

关键词：

LYMPHOKINE; J774; MACROPHAGES; MACROPHAGE ACTIVATION; GROWTH FACTOR;

D O I：

10.1002/jlb.49.6.587

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We evaluated the effects of murine recombinant interleukin-4 (rIL-4) on murine peritoneal macrophages. We showed a marked, dose-dependent stimulation of respiratory oxidative burst by IL-4 in peptone-elicited murine peritoneal macrophages. This effect was abolished by a neutralizing monoclonal antibody (mAb) to rIL-4 confirming that the enhanced chemiluminescence was due to IL-4. In contrast, rIL-4 depressed the respiratory oxidative burst of a transformed murine macrophage cell line, J774, in a dose-dependent mAb-reversible manner.

引用

页码：587 / 591

页数：5

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