BLAST CRISIS IN A MURINE MODEL OF CHRONIC MYELOGENOUS LEUKEMIA

被引：94

作者：

DALEY, GQ ^{[1
]}

VANETTEN, RA ^{[1
]}

BALTIMORE, D ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期

关键词：

BCR/ABL; ABELSON MURINE LEUKEMIA VIRUS; HEMATOPOIETIC STEM CELL;

D O I：

10.1073/pnas.88.24.11335

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The P210bcr/abl protein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/abl into murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.

引用

页码：11335 / 11338

页数：4

共 25 条

[1]

BARNETT MJ, 1989, BONE MARROW TRANSPL, V4, P345

[2] THE CHRONIC MYELOGENOUS LEUKEMIA SPECIFIC P210-PROTEIN IS THE PRODUCT OF THE BCR/ABL HYBRID GENE [J].