LACK OF EVIDENCE FOR PERFLUORODECANOYL- OR PERFLUOROOCTANOYL-COENZYME-A FORMATION IN MALE AND FEMALE RATS

被引：44

作者：

KUSLIKIS, BI

VANDENHEUVEL, JP

PETERSON, RE

机构：

[1] UNIV WISCONSIN, SCH PHARM, 425 N CHARTER ST, MADISON, WI 53706 USA

[2] UNIV WISCONSIN, CTR ENVIRONM TOXICOL, MADISON, WI 53706 USA

来源：

JOURNAL OF BIOCHEMICAL TOXICOLOGY | 1992年 / 7卷 / 01期

关键词：

PERFLUORODECANOIC ACID; PERFLUOROOCTANOIC ACID; METABOLISM; PEROXISOME PROLIFERATION; COENZYME-A;

D O I：

10.1002/jbt.2570070106

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a CoA conjugate of clofibric acid, no corresponding CoA derivative could be found for either PFDA or PFOA.

引用

页码：25 / 29

页数：5

共 16 条

[1] THE HYPOLIPIDEMIC PEROXISOME-PROLIFERATING DRUG, BIS(CARBOXYMETHYLTHIO)-1.10 DECANE, A DICARBOXYLIC METABOLITE OF TIADENOL, IS ACTIVATED TO AN ACYLCOENZYME-A THIOESTER [J].