ROLE OF THE CD45 TYROSINE PHOSPHATASE IN SIGNAL TRANSDUCTION IN THE IMMUNE-SYSTEM

被引：72

作者：

KORETZKY, GA ^{[1
]}

机构：

[1] UNIV IOWA,COLL MED,DEPT PHYSIOL & BIOPHYS,IOWA CITY,IA 52242

来源：

FASEB JOURNAL | 1993年 / 7卷 / 05期

关键词：

TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; CD45; T-CELL RECEPTOR; TYROSINE KINASE;

D O I：

10.1096/fasebj.7.5.8462784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.

引用

页码：420 / 426

页数：7

共 82 条

[1] ACTIVATION OF P56LCK THROUGH MUTATION OF A REGULATORY CARBOXY-TERMINAL TYROSINE RESIDUE REQUIRES INTACT SITES OF AUTOPHOSPHORYLATION AND MYRISTYLATION
ABRAHAM, N
VEILLETTE, A
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) : 5197 - 5206
[2] ENHANCEMENT OF T-CELL RESPONSIVENESS BY THE LYMPHOCYTE-SPECIFIC TYROSINE PROTEIN-KINASE P56LCK
ABRAHAM, N
MICELI, MC
PARNES, JR
VEILLETTE, A
[J]. NATURE, 1991, 350 (6313) : 62 - 66
[3] DEFECTIVE T-CELL RECEPTOR SIGNALING IN MICE LACKING THE THYMIC ISOFORM OF P59(FYN)
APPLEBY, MW
GROSS, JA
COOKE, MP
LEVIN, SD
QIAN, X
PERLMUTTER, RM
[J]. CELL, 1992, 70 (05) : 751 - 763
[4] PHORBOL DIESTERS INCREASE THE PHOSPHORYLATION OF THE LEUKOCYTE COMMON ANTIGEN CD45 IN HUMAN T-CELLS
AUTERO, M
GAHMBERG, CG
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (10) : 1503 - 1506
[5] BELL G M, 1991, Arthritis and Rheumatism, V34, pS79
[6] TYROSINE PHOSPHORYLATION COUPLED TO IGE RECEPTOR-MEDIATED SIGNAL TRANSDUCTION AND HISTAMINE-RELEASE
BENHAMOU, M
GUTKIND, JS
ROBBINS, KC
SIRAGANIAN, RP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5327 - 5330
[7] INOSITOL PHOSPHATES AND CELL SIGNALING
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1989, 341 (6239) : 197 - 205
[8] CHANGES IN CD45 ISOFORM EXPRESSION ACCOMPANY ANTIGEN-INDUCED MURINE T-CELL ACTIVATION
BIRKELAND, ML
JOHNSON, P
TROWBRIDGE, IS
PURE, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) : 6734 - 6738
[9] A MONOCLONAL-ANTIBODY TO MURINE CD45R DISTINGUISHES CD4 T-CELL POPULATIONS THAT PRODUCE DIFFERENT CYTOKINES
BOTTOMLY, K
LUQMAN, M
GREENBAUM, L
CARDING, S
WEST, J
PASQUALINI, T
MURPHY, DB
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (04) : 617 - 623
[10] CAMPBELL MA, 1992, MOL CELL BIOL, V12, P2314

← 1 2 3 4 5 6 7 8 9 →