A COMMON PROVIRAL INTEGRATION REGION, FIT-1, IN T-CELL TUMORS INDUCED BY MYC-CONTAINING FELINE LEUKEMIA VIRUSES

被引:25
作者
TSUJIMOTO, H
FULTON, R
NISHIGAKI, K
MATSUMOTO, Y
HASEGAWA, A
TSUJIMOTO, A
CEVARIO, S
OBRIEN, SJ
TERRY, A
ONIONS, D
NEIL, JC
机构
[1] UNIV GLASGOW,DEPT VET PATHOL,MOLEC ONCOL LAB,GLASGOW G61 1QH,SCOTLAND
[2] UNIV TOKYO,DEPT VET INTERNAL MED,TOKYO 113,JAPAN
[3] BEATSON INST CANC RES,GLASGOW G61 1BD,SCOTLAND
[4] NATL CANC CTR,RES INST,TOKYO 104,JAPAN
[5] NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21202
关键词
D O I
10.1006/viro.1993.1544
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Feline leukemia viruses carrying transduced v-myc genes (myc-FeLV) induce tumors of clonel origin, suggesting that activated myc alone is not sufficient for tumorgenesis. To investigate the hypothesis that insertional mutagenesis plays a role by activating genes which collaborate with v-myc, we looked for evidence of common proviral integration sites in these tumors. By inverse polymerase chain reaction we identified a 6-kb domain, designated fit-1, in which FeLV proviruses were inserted in four of nine (44%) T-cell tumors induced by myc-FeLV. The fit-1 locus was mapped to feline chromosome B2 and appears to be distinct from known oncogenes located on this chromosome. Fit-1 represents a novel common proviral integration region which may harbor a cellular gene which acts in concert with the myc gene in T-cell tumorigenesis. © 1993 Academic Press. All rights reserved.
引用
收藏
页码:845 / 848
页数:4
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