EXTENSION OF THE ESCHWEILER-CLARKE PROCEDURE TO THE N-ALKYLATION OF AMIDES

被引：33

作者：

FACHE, F

JACQUOT, L

LEMAIRE, M

机构：

[1] INST RECH CATALYSE,CATALYSE & SYNTH ORGAN LAB,F-69622 VILLEURBANNE,FRANCE

[2] UNIV LYON 1,ESCIL,F-69622 VILLEURBANNE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76894-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na2SO4 as catalyst. Good isolated yields are obtained (81% to 98%).

引用

页码：3313 / 3314

页数：2

共 6 条

[1]

GAJDA T, 1981, SYNTHESIS-STUTTGART, P1005

[2]

March J, 1985, ADV ORG CHEM, P798

[3] SYNTHESIS OF 2-AZETIDINONES FROM SERINEHYDROXAMATES - APPROACHES TO THE SYNTHESIS OF 3-AMINONOCARDICINIC ACID [J].

MATTINGLY, PG ;

MILLER, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (08) :1557-1564

[4] THE SELECTIVE N-MONOALKYLATION OF AMIDES WITH ALKYL-HALIDES IN THE PRESENCE OF ALUMINA AND KOH [J].

SUKATA, K .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1985, 58 (03) :838-843

[5] THE RUTHENIUM CATALYZED N-ALKYLATION OF AMIDES WITH ALCOHOLS [J].

WATANABE, Y ;

OHTA, T ;

TSUJI, Y .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (09) :2647-2651

[6] N-ALKYLATION OF AMIDES AND N-HETEROCYCLES WITH POTASSIUM FLUORIDE ON ALUMINA [J].

YAMAWAKI, J ;

ANDO, T ;

HANAFUSA, T .

CHEMISTRY LETTERS, 1981, (08) :1143-1146

← 1 →