UBIQUINOL-3 AND UBIQUINOL-7 EXHIBIT SIMILAR ANTIOXIDANT ACTIVITY IN MODEL MEMBRANES

被引：11

作者：

FIORENTINI, D

CABRINI, L

LANDI, L

机构：

[1] Dipartimento di Biochimica, G. Moruzzi Università di Bologna, 40126 Bologna, Via Irnerio

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1993年 / 18卷 / 04期

关键词：

UBIQUINOL; UBIQUINONE; ANTIOXIDANT; LIPOSOME; LIPID AUTOXIDATION; AZO-INITIATORS;

D O I：

10.3109/10715769309145869

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was undertaken to compare, on a kinetic basis, the antioxidant efficiency of an ubiquinol homologue having a short isoprenoid side-chain length, such as ubiquinol-3, with that of the long chain ubiquinol-7, by determining their rate constants of inhibition with respect to alpha-tocopherol. To this purpose we incorporated ubiquinol-3, or ubiquinol-7, or alpha-tocopherol into liposomes of egg yolk lecithin, and triggered lipid peroxidation with the thermal decomposition of a lipophilic azocompound. The results show that: i) the rate constants of inhibition for the two quinols are similar and slightly lower than that of alpha-tocopherol; ii) the length of the radical chain obtained in the presence of the two quinols is almost the same. From these data we concluded that the two homologues tested behave as chain-breaking antioxidants with quite similar effectiveness.

引用

页码：201 / 209

页数：9

共 18 条

[1] AUTOXIDATION OF BIOLOGICAL MOLECULES .2. THE AUTOXIDATION OF A MODEL MEMBRANE - A COMPARISON OF THE AUTOXIDATION OF EGG LECITHIN PHOSPHATIDYLCHOLINE IN WATER AND IN CHLOROBENZENE [J].