A SHARED EPITOPE FOUND IN THE MAJOR PARALYSIS INDUCING TICK SPECIES OF AFRICA

被引：9

作者：

CRAUSE, JC

VANWYNGAARDT, S

GOTHE, R

NEITZ, AWH

机构：

[1] Department of Biochemistry, University of Pretoria, Pretoria

[2] Institute for Comparative Tropical Medicine and Parasitology, University of Munich, Munich 40

来源：

EXPERIMENTAL & APPLIED ACAROLOGY | 1994年 / 18卷 / 01期

关键词：

D O I：

10.1007/BF00051402

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Cross-reactivity between all the paralysis inducing tick species of veterinary relevance in Africa was demonstrated, by using a monoclonal antibody directed against the paralysis inducing toxin of Rhipicephalus evertsi evertsi. Western blot results, together with amino acid composition studies indicated that this monoclonal antibody recognizes protein bands of similar molecular mass and amino acid composition in R. evertsi evertsi and Ixodes rubicundus. This suggests that the Karoo paralysis toxin of L rubicundus is possibly also a trimer with a high degree of homology to the spring lamb paralysis toxin of R. evertsi evertsi. The conclusive identity of these protein bands of L rubicundus could not be shown. Bio-assay studies performed on 1-day-old chickens suggested that the anti-spring lamb paralysis toxin monoclonal antibody also recognizes the paralysis toxin present in Argas (Persicargas) walkerae, by rendering some degree of protection against the effect of this toxin.

引用

页码：51 / 59

页数：9

共 14 条

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[2]

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