RILUZOLE AND EXPERIMENTAL PARKINSONISM - ANTAGONISM OF MPTP-INDUCED DECREASE IN CENTRAL DOPAMINE LEVELS IN MICE

被引：57

作者：

BOIREAU, A

DUBEDAT, P

BORDIER, F

PENY, C

MIQUET, JM

DURAND, G

MEUNIER, M

DOBLE, A

机构：

[1] RhÚne-Poulenc Rorer S.A, Centre de Recherche de Vitry-Alfortville, Département Biologie, Vitry-sur-Seine, 94403

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

DOPAMINE; RILUZOLE; MPTP; EXCITOTOXICITY; PARKINSONS DISEASE;

D O I：

10.1097/00001756-199412000-00063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

WE have investigated whether riluzole, a compound that interferes with glutamatergic (GLUergic) transmission, would protect central dopaminergic (DAergic) neurones from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity in the striatum in mice. MPTP decreased DA, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels. Riluzole protected against the MPTP-induced decrease in DA levels. The utilization of DA ([DOPAC + HVA]/DA) was increased after MPTP treatment, but returned to control values in mice given riluzole in combination with MPTP. Riluzole did not confer protection by inhibiting either monoamine oxidase type B activity or DA uptake. Possible mechanisms involved in the protective action of riluzole are discussed. Our results show that riluzole antagonizes the DAergic neurotoxicity of MPTP, a pro-parkinsonian neurotoxin, in mice.

引用

页码：2657 / 2660

页数：4

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