DOSE-RESPONSE RELATIONSHIPS OF MICRONUCLEI IN HUMAN-LYMPHOCYTES INDUCED BY FISSION NEUTRONS AND BY LOW LET RADIATIONS

被引：33

作者：

HUBER, R ^{[1
]}

SCHRAUBE, H ^{[1
]}

NAHRSTEDT, U ^{[1
]}

BRASELMANN, H ^{[1
]}

BAUCHINGER, M ^{[1
]}

机构：

[1] GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT,INST RADIAT PROTECT,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

MUTATION RESEARCH | 1994年 / 306卷 / 02期

关键词：

CYTOKINESIS-BLOCKED MICRONUCLEUS ASSAY; FISSION NEUTRONS; HUMAN LYMPHOCYTES;

D O I：

10.1016/0027-5107(94)90024-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The induction of micronuclei in cytokinesis-blocked human lymphocytes of different donors has been measured after G(0) irradiation in vitro with a mixed fission neutron-gamma-ray beam, 220 kV gamma-rays and Co-60 gamma-rays. The dose-response relationships for the micronucleus yields were linear-quadratic for both types of low LET radiations. The linear model applied for neutron-induced micronuclei over the dose range 0-0.66 Gy. At higher doses a saturation effect became apparent. For neutron-induced micronucleus yields a limiting RBE value of 12.2 was derived from the ratio of the alpha coefficients of neutrons and Co-60 gamma-rays.

引用

页码：135 / 141

页数：7

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