BINDING OF I-125 IODOVINYLTETRABENAZINE TO CNS VESICULAR MONOAMINE TRANSPORT SITES

被引：21

作者：

KUNG, MP ^{[1
]}

CANNEY, DJ ^{[1
]}

FREDERICK, D ^{[1
]}

ZHUANG, Z ^{[1
]}

BILLINGS, JJ ^{[1
]}

KUNG, HF ^{[1
]}

机构：

[1] UNIV PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19104

来源：

SYNAPSE | 1994年 / 18卷 / 03期

关键词：

VESICULAR MONOAMINE TRANSPORT (VMAT) SITES; I-125; TBZ; HOMOGENATE BINDING; AUTORADIOGRAPHY; CNS;

D O I：

10.1002/syn.890180308

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Binding characteristics of a novel radioiodinated tetrabenazine (TBZ) analog (iodovinyltetrabenazine; I-125-TBZ-Fraction I) were evaluated. In rat striatal homogenates, I-125-TBZ-I displayed a pharmacological profile consistent with specific binding to vesicular monoamine transport (VMAT) sites. In vitro autoradiographic studies using rat brain sections further demonstrated that I-125-TBZ-I labeled the regions rich in VMAT sites, and it may be a useful marker for these sites. This novel radioiodinated ligand, with high specific activity and high binding affinity, may provide a powerful tool for the in vitro assessment of neuronal loss in various neurodegenerative diseases. (C) 1994 Wiley-Liss, Inc.

引用

页码：225 / 232

页数：8

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