DEVELOPMENT OF AN ESTRIOL-RELEASING INTRA-UTERINE DEVICE

被引：19

作者：

BAKER, RW ^{[1
]}

TUTTLE, ME ^{[1
]}

LONSDALE, HK ^{[1
]}

AYRES, JW ^{[1
]}

机构：

[1] OREGON STATE UNIV,SCH PHARM,CORVALLIS,OR 97331

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Dosage forms—intrauterine devices; estriol releasing; prepared; release rate and stability evaluated; Estriol—delivered by intrauterine devices; Estrogens—estriol; delivered by intrauterine devices; Intrauterine devices—estriol releasing;

D O I：

10.1002/jps.2600680110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Estriol‐releasing intrauterine devices were developed for experimental use in animals and humans. The devices consist of a reservoir containing the steroid surrounded by a rate‐limiting polyurethane membrane. After an initial transient, the drug is released from the device at a constant rate for 1 year or more; devices with a much longer release period can be fabricated readily. A constant release rate is achieved by maintaining solid drug in the reservoir and good physical contact between the drug and the inside wall of the device. The methods used to fabricate the devices are described along with release rate and stability data. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：20 / 26

页数：7

共 16 条

[1]

Baker R.W., 1974, CONTROLLED RELEASE B

[2]

Boretos J W, 1971, J Biomed Mater Res, V5, P373, DOI 10.1002/jbm.820050408

[3]

CRANK J, 1967, MATH DIFFUSION

[4]

DMOWSKI WP, 1977, FERTIL STERIL, V28, P262

[5]

GIBOR Y, 1971, FERTIL STERIL, V22, P671

[6] RELEASE OF PROGESTERONE-H-3 FROM POLYMERIC SYSTEMS IN RHESUS-MONKEY [J].

KULKARNI, BD ;

AVILA, TD ;

PHARRISS, BB ;

SCOMMEGNA, A .

CONTRACEPTION, 1973, 8 (04) :299-314

[7]

LEHMAN K, 1967, DRUGS MADE GERMANY, V10, P115

[8]

LIFCHEZ AS, 1970, FERTIL STERIL, V21, P426

[9] TRANSPORT PROPERTIES OF CELLULOSE ACETATE OSMOTIC MEMBRANES [J].

LONSDALE, HK ;

MERTEN, U ;

RILEY, RL .

JOURNAL OF APPLIED POLYMER SCIENCE, 1965, 9 (04) :1341-&

[10]

NOLL CA, 1969, Patent No. 3468796

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