TRNA-DEPENDENT TRANSLATIONAL CONTROL OF IN VITRO HEMOGLOBIN SYNTHESIS

被引：46

作者：

ANDERSON, WF

GILBERT, JM

机构：

[1] Section on Human Biochemistry, Laboratory of Clinical Biochemistry, National Heart Institute, Bethesda

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 03期

关键词：

D O I：

10.1016/0006-291X(69)90586-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A tRNA-dependent rabbit reticulocyte cell-free system has been developed which is highly active in synthesizing hemoglobin. When unfractionated tRNA is used to supplement the system, approximately equal amounts of α and β chains are produced. When tRNA fractionated by Freon reverse phase chromatography is utilized, but with a specific portion deleted, α chain production is reduced to approximately 67% of the production of β chains. © 1969.

引用

页码：456 / &

共 16 条

[1] EFFECT OF TRNA CONCENTRATION ON RATE OF PROTEIN SYNTHESIS
ANDERSON, WF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 62 (02) : 566 - &
[2] ANDERSON WF, 1968, FED PROC, V27, P341
[3] HAEMOGLOBIN SYNTHESIS IN BETA-THALASSAEMIA
CLEGG, JB
WEATHERALL, DJ
NANAKORN, S
WASI, P
[J]. NATURE, 1968, 220 (5168) : 664 - +
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[5] DAYHOFF MO, 1967, ATLAS PROTEIN SEQUEN, P142
[6] ASSEMBLY OF PEPTIDE CHAINS OF HEMOGLOBIN
DINTZIS, HM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1961, 47 (03) : 247 - +
[7] SPECIFICITY OF SERINE TRANSFER RIBONUCLEIC ACIDS IN SYNTHESIS OF HEMOGLOBIN
GONANO, F
[J]. BIOCHEMISTRY, 1967, 6 (04) : 977 - &
[8] ITANO HA, 1965, ABNORMAL HAEMOGLOBIN, P3
[9] JONXIS JHP, 1965, ABNORMAL HAEMOGLO ED, P3
[10] ISOLATION OF A PROTEIN FRACTION FROM RETICULOCYTE RIBOSOMES REQUIRED FOR DE NOVO SYNTHESIS OF HEMOGLOBIN
MILLER, RL
SCHWEET, R
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 125 (02) : 632 - &

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