INCREASED VON WILLEBRAND FACTOR IN DIABETES-MELLITUS

被引：118

作者：

LUFKIN, EG ^{[1
]}

FASS, DN ^{[1
]}

OFALLON, WM ^{[1
]}

BOWIE, EJW ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,HEMATOL RES SECT,ROCHESTER,MN 55901

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1979年 / 28卷 / 01期

关键词：

D O I：

10.1016/0026-0495(79)90169-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormal platelet function may play a role in the genesis of vascular complications in diabetes mellitus. We measured plasma levels of ristocetin-Willebrand factor and factor VIII antigen in 75 subjects and also measured aggregation-enhancing factor in subsets. We found increased levels of ristocetin-Willebrand factor in all groups of diabetics studied, even in mild diabetics free of vascular disease. Factor VIII antigen was increased only in diabetics with vascular disease. We could not find an aggregation-enhancing factor in any group. © 1979.

引用

页码：63 / 66

页数：4

共 20 条

[1] PLATELET HYPERAGGREGATION AND INCREASED PLASMA-LEVEL OF VONWILLEBRAND FACTOR IN DIABETICS WITH RETINOPATHY [J].

BENSOUSSAN, D ;

LEVYTOLEDANO, S ;

PASSA, P ;

CAEN, J ;

CANIVET, J .

DIABETOLOGIA, 1975, 11 (04) :307-312

[2]

BOWIE EJW, 1975, THROMB DIATH HAEMOST, V34, P599

[3] PLASMA COFACTORS OF PLATELET-FUNCTION - CORRELATION WITH DIABETIC-RETINOPATHY AND HEMOGLOBINS ALA-C - STUDIES IN DIABETIC-PATIENTS AND NORMAL PERSONS [J].

COLLER, BS ;

FRANK, RN ;

MILTON, RC ;

GRALNICK, HR .

ANNALS OF INTERNAL MEDICINE, 1978, 88 (03) :311-316

[4] EFFECT OF STIR BAR SIZE AND SHAPE ON QUANTITATIVE PLATELET-AGGREGATION [J].

COLLER, BS ;

GRALNICK, HR .

THROMBOSIS RESEARCH, 1976, 8 (02) :121-129

[5] CORRELATION OF PLATELET-AGGREGATION, PLASMA FACTOR ACTIVITY, AND MEGA-THROMBOCYTES IN DIABETIC SUBJECTS WITH AND WITHOUT VASCULAR-DISEASE [J].

COLWELL, JA ;

SAGEL, J ;

CROOK, L ;

CHAMBERS, A ;

LAIMINS, M .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1977, 26 (03) :279-285

[6]

CONDON T, 1974, LANCET, V2, P1345

[7]

DOLL R, 1972, Journal of the Royal College of Physicians of London, V6, P216

[8] RESISTANCE TO ARTERIOSCLEROSIS IN PIGS WITH VONWILLEBRANDS DISEASE - SPONTANEOUS AND HIGH CHOLESTEROL DIET-INDUCED ARTERIOSCLEROSIS [J].

FUSTER, V ;

BOWIE, EJW ;

LEWIS, JC ;

FASS, DN ;

OWEN, CA ;

BROWN, AL .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (03) :722-730

[9]

HOLMBERG L, 1974, SCAND J HAEMATOL, V12, P221

[10]

KWANN HC, 1972, J LAB CLIN MED, V80, P236

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