A CD4-LIKE MOLECULE CAN BE EXPRESSED INVIVO IN HUMAN PARATHYROID

被引：10

作者：

FAURE, GC

TANG, JQ

MATHIEU, P

BENE, MC

机构：

[1] UFR SCI MED NANCY, IMMUNOL LAB, F-54500 VANDOEUVRE LES NANCY, FRANCE

[2] UFR SCI MED NANCY, CHIRURG LAB A, F-54500 VANDOEUVRE LES NANCY, FRANCE

[3] CHU BRABOIS, F-54500 VANDOEUVRE LES NANCY, FRANCE

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 71卷 / 03期

关键词：

D O I：

10.1210/jcem-71-3-656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of several epitopes of CD4, a molecule usually restricted to a subset of T-lymphocytes, was observed after immunofluorescent labeling of frozen-cut sections of human parathyroid. Seven samples obtained from three subjects presenting adenomas and from seven renal insufficiency patients with secondary or tertiary hyperplasia were found to express this molecule. Dot enzyme-linked immunosorbant assay, polyacrylamide gel electrophoresis, and Western blotting were used to characterize this peptide in cytosol and membrane fractions of these glands. These studies confirmed, in the parathyroids found positive in immunofluorescence, the presence of a protein with a mol wt similar to that of lymphocyte-derived CD4. © 1990 by The Endocrine Society.

引用

页码：656 / 660

页数：5

共 18 条

[1] POSSIBLE INVOLVEMENT OF THE OKT4 MOLECULE IN T-CELL RECOGNITION OF CLASS-II HLA ANTIGENS - EVIDENCE FROM STUDIES OF CYTO-TOXIC LYMPHOCYTES-T SPECIFIC FOR SB ANTIGENS [J].