LACK OF ANTINOCICEPTIVE ACTIVITY OF SUMATRIPTAN IN RODENTS

被引：49

作者：

SKINGLE, M

BIRCH, PJ

LEIGHTON, GE

HUMPHREY, PPA

机构：

[1] Department of Neuropharmacology, Glaxo Group Research Ltd, Ware, Herts S.G., 12 0DP, Park Road

[2] Parke-Davies Research Unit, Cambridge

来源：

CEPHALALGIA | 1990年 / 10卷 / 05期

关键词：

Antinociceptive 5–HT migraine; serotonin; sumatriptan;

D O I：

10.1046/j.1468-2982.1990.1005207.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action. © 1990, International Headache Society. All rights reserved.

引用

页码：207 / 212

页数：6

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