NEW SYNTHESIS OF 8-CHLORO-1-[2-(DIMETHYLAMINO)ETHYL]-6-PHENYL-4H-S-TRIAZOLO[4,3-A][1,4]-BENZODIAZEPINE, WHICH HAS ANTI-DEPRESSANT PROPERTIES

被引：14

作者：

HESTER, JB

机构：

[1] Research Laboratories, The Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 23期

关键词：

D O I：

10.1021/jo01337a032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, regiospecific synthesis of 8-chloro-l-[2-(dimethylamino)ethyl]-6-phenyl-4/i-s-triazolo[4, 3-o] [1, 4]benzodiazepine by an acetyl chloride catalyzed addition of dimethyl(methylene)ammonium chloride to 8-chloro-l-methyl-6-phenyl-4if-s-triazolo[4, 3-a][l, 4]benzodiazepine is described. A limited investigation of the scope of this reaction is also presented. Copyright © 1979, American Chemical Society. All rights reserved.

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页码：4165 / 4169

页数：5

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