BER-H2 (ANTI-CD30)-SAPORIN IMMUNOTOXIN - A NEW TOOL FOR THE TREATMENT OF HODGKINS-DISEASE AND CD30 PLUS LYMPHOMA INVITRO EVALUATION

被引：74

作者：

TAZZARI, PL

BOLOGNESI, A

DETOTERO, D

FALINI, B

LEMOLI, RM

SORIA, MR

PILERI, S

GOBBI, M

STEIN, H

FLENGHI, L

MARTELLI, MF

STIRPE, F

机构：

[1] UNIV BOLOGNA, DIPARTIMENTO PATOL SPERIMENTALE, VIA S GIACOMO 14, I-40126 BOLOGNA, ITALY

[2] IST NAZL RIC CANC, GENOA, ITALY

[3] POLICLIN MONTELUCE, IST EMATOL, PERUGIA, ITALY

[4] UNIV BOLOGNA, IST EMATOL, I-40126 BOLOGNA, ITALY

[5] IST SCI BIOMED S RAFFAELE, DIPARTIMENTO BIOTECNOL, MILAN, ITALY

[6] DIPARTIMENTO MED INTERNA, CATTEDRA EMATOL, GENOA, ITALY

[7] FREE UNIV BERLIN, INST PATHOL, W-1000 BERLIN 33, GERMANY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1992年 / 81卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1992.tb08208.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a verv high efficiency (IC50 ranging from 5 x 10(-12) M to 5 X 10(-14) M, as saporin), while irrelevant immunotoxins do not. Present results suggest that this immunotoxin could be used for in vivo therapy as well as for ex vivo bone marrow purging in Hodgkin's disease and CD30+ lymphomas.

引用

页码：203 / 211

页数：9

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