ABERRANT REARRANGEMENTS CONTRIBUTE SIGNIFICANTLY TO THE ALLELIC EXCLUSION OF IMMUNOGLOBULIN GENE-EXPRESSION

被引：335

作者：

COLECLOUGH, C ^{[1
]}

PERRY, RP ^{[1
]}

KARJALAINEN, K ^{[1
]}

WEIGERT, M ^{[1
]}

机构：

[1] FOX CHASE CANC CTR,INST CANC RES,PHILADELPHIA,PA 19111

来源：

NATURE | 1981年 / 290卷 / 5805期

关键词：

D O I：

10.1038/290372a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：372 / 378

页数：7

共 32 条

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CELL, 1980, 21 (01) :1-12

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[4] COMPLETE IMMUNOGLOBULIN GENE IS CREATED BY SOMATIC RECOMBINATION [J].

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[5] RNA SPLICING GENERATES A VARIANT LIGHT CHAIN FROM AN ABERRANTLY REARRANGED K-GENE [J].

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NATURE, 1980, 286 (5775) :776-779

[6] REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES DURING BETA-LYMPHOCYTE DEVELOPMENT AS REVEALED BY STUDIES OF MOUSE PLASMACYTOMA CELLS [J].

COLECLOUGH, C ;

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1422-1426

[7] SOMATIC REARRANGEMENTS FORMING ACTIVE IMMUNOGLOBULIN MU-GENES IN B-LYMPHOID AND T-LYMPHOID CELL-LINES [J].

CORY, S ;

ADAMS, JM ;

KEMP, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (08) :4943-4947

[8] IMMUNOGLOBULIN HEAVY-CHAIN GENE IS FORMED BY AT LEAST 2 RECOMBINATIONAL EVENTS [J].

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HOOD, L .

NATURE, 1980, 283 (5749) :733-739

[9] AN IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION GENE IS GENERATED FROM 3 SEGMENTS OF DNA - VH, D AND JH [J].

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CELL, 1980, 19 (04) :981-992

[10] CH GENE REARRANGEMENTS IN IGM-BEARING B-CELLS AND IN THE NORMAL SPLENIC DNA COMPONENT OF HYBRIDOMAS MAKING DIFFERENT ISOTYPES OF ANTIBODY [J].

HURWITZ, JL ;

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CEBRA, JJ .

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