NUCLEOTIDE-SEQUENCE OF CLASS-D TETRACYCLINE RESISTANCE GENES FROM SALMONELLA-ORDONEZ

被引:27
作者
ALLARD, JD
GIBSON, ML
VU, LH
NGUYEN, TT
BERTRAND, KP
机构
[1] WASHINGTON STATE UNIV,DEPT MICROBIOL,PULLMAN,WA 99164
[2] UNIV CALIF IRVINE,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717
[3] WASHINGTON STATE UNIV,DEPT BIOCHEM & BIOPHYS,PULLMAN,WA 99164
来源
MOLECULAR & GENERAL GENETICS | 1993年 / 237卷 / 1-2期
关键词
TETRACYCLINE RESISTANCE; CLASS-D TETA; INSERTION SEQUENCE IS26; SALMONELLA-ORDONEZ;
D O I
10.1007/BF00282811
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Plasmid pIP173, isolated from Salmonella ordonez strain BM2000, confers resistance to tetracycline and a number of other antibiotics. We determined the nucleotide sequence of the pIP173 tetR repressor and tetA resistance genes. The pIP173 tetR gene is essentially identical to the class D tetR gene from plasmid RA1. The pIP173 tet genes are flanked by directly repeated copies of the insertion sequence IS26. Interestingly, the 3' end of the tetR gene, encoding the C-terminal 16 amino acids of the TetR protein, extends into the flanking IS26 sequence. The relationships between the class A, B, C, and D TetA sequences parallel the relationships between the corresponding TetR sequences; class D is more closely related to class B than to either class A or C. Overall, the four TetA sequences show 38% identity and 57% similarity.
引用
收藏
页码:301 / 305
页数:5
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