SIALOADHESIN (SN) MAPS TO MOUSE CHROMOSOME-2 AND HUMAN-CHROMOSOME-20 AND IS NOT LINKED TO THE OTHER MEMBERS OF THE SIALOADHESIN FAMILY, CD22, MAG, AND CD33

被引：15

作者：

MUCKLOW, S

HARTNELL, A

MATTEI, MG

GORDON, S

CROCKER, PR

机构：

[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOLEC MED,IMPERIAL CANC RES FUND,MOLEC HAEMOPOIESIS LAB,OXFORD OX3 9DU,ENGLAND

[2] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,OXFORD OX3 9DU,ENGLAND

[3] FAC MED MARSEILLE,INSERM,U406,UNITE GENET MED & DEV,F-13385 MARSEILLE 5,FRANCE

来源：

GENOMICS | 1995年 / 28卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/geno.1995.1153

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sialoadhesin is a cell-cell interaction molecule expressed by subpopulations of tissue macrophages. It contains 17 immunoglobulin (Ig)-like domains and is structurally related to CD22, MAG, and CD33. These molecules establish a distinct family of sialic acid-dependent adhesion molecules, the sialoadhesin family. We have mapped the rodent sialoadhesin gene, Sn, to chromosome 2F-H1 by in situ hybridization (ISH) and shown linkage to Il1b and four other markers by backcross linkage analysis. We have also used ISH and a human-mouse somatic cell hybrid panel to localize the human sialoadhesin gene, SN, to the conserved syntenic region on human chromosome 20p13. This demonstrates that the sialoadhesin gene is not linked to the other members of the Sialoadhesin family, CD22, MAG, and CD33, which have been independently mapped to the distal region of mouse chromosome 7 and to human chromosome 19q13.1-3. (C) 1995 Academic Press, Inc.

引用

页码：344 / 346

页数：3

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