DECREASED GABA IMMUNOREACTIVITY IN SPINAL-CORD DORSAL HORN NEURONS AFTER TRANSIENT SPINAL-CORD ISCHEMIA IN THE RAT

被引：96

作者：

ZHANG, AL

HAO, JX

SEIGER, A

XU, XJ

WIESENFELDHALLIN, Z

GRANT, G

ALDSKOGIUS, H

机构：

[1] KAROLINSKA INST,DEPT NEUROSCI,NEUROANAT & PLASTIC SECT,STOCKHOLM,SWEDEN

[2] KAROLINSKA INST,DEPT CLIN NEUROSCI & FAMILY MED,GERIATR MED SECT,HUDDINGE,SWEDEN

[3] KAROLINSKA INST,DEPT MED LAB SCI & TECHNOL,CLIN NEUROPHYSIOL SECT,HUDDINGE,SWEDEN

来源：

BRAIN RESEARCH | 1994年 / 656卷 / 01期

关键词：

GABA IMMUNOREACTIVITY; SPINAL CORD; DORSAL HORN NEURON; ISCHEMIA;

D O I：

10.1016/0006-8993(94)91383-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The number of GABA-like immunoreactive (LI) cells in lamina I-III of the rat spinal cord was significantly decreased bilaterally 48-72 h after photochemical induction of transient spinal cord ischemia compared to sham-operated controls. No significant changes in the number of GABA-LI cells were observed at cervical level. The number of GABA-LI cells was restored 2 weeks after ischemia. These data, together with recent behavioral and electrophysiological findings, suggest that decreased intraneuronal GABA levels after spinal cord ischemia may underlie the development of the temporary pain-like response to innocuous mechanical stimuli (allodynia) in rats after transient spinal cord ischemia.

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收藏

页码：187 / 190

页数：4

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