CELL-CYCLE CONTROL OF MORPHOGENESIS IN BUDDING YEAST

被引：201

作者：

LEW, DJ ^{[1
]}

REED, SI ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(95)90048-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A detailed description of the cytoskeletal rearrangements that orchestrate bud formation is beginning to emerge from studies on yeast morphogenesis. In this review, we focus on recent advances in our understanding of how the timing of these rearrangements is controlled. Dramatic changes in cell polarity that occur in G(1) (polarization to the bud site), G(2) (depolarization within the bud), and mitosis (repolarization to the mother/bud neck) are triggered by changes in the kinase activity of Cdc28, the universal regulator of cell cycle progression. The hunt for Cdc28 morphogenesis substrates is on.

引用

页码：17 / 23

页数：7

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