ALTERED GABAERGIC AND GLUTAMATERGIC TRANSMISSION IN AUDIOGENIC SEIZURE-SUSCEPTIBLE MICE

被引：11

作者：

CORDERO, ML

ORTIZ, JG

SANTIAGO, G

NEGRON, A

MOREIRA, JA

机构：

[1] Department of Pharmacology, University of Puerto Rico, School of Medicine, San Juan, 00936-5067, Puerto Rico

来源：

MOLECULAR NEUROBIOLOGY | 1994年 / 9卷 / 1-3期

关键词：

GLUTAMATE; GABA; AUDIOGENIC SEIZURES; EPILEPSY; UPTAKE; RELEASE;

D O I：

10.1007/BF02816124

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminotransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate aminotransferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA uptake is decreased in cortex, midbrain, and pens medulla. Previous studies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SPS) mice. Glutamate U-max by System 1 is significantly decreased in these mice, whereas the U-max value for System 2 is significantly increased in the epileptic mice.

引用

页码：253 / 258

页数：6

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