INTERETHNIC DIFFERENCES IN DRUG PROTEIN-BINDING AND ALPHA(1) ACID GLYCOPROTEIN CONCENTRATION

被引：10

作者：

HOSSEINE, SJ ^{[1
]}

FARID, R ^{[1
]}

GHALIGHI, MR ^{[1
]}

FEELY, J ^{[1
]}

机构：

[1] UNIV DUBLIN TRINITY COLL,DEPT THERAPEUT & PHARMACOL,DUBLIN 2,IRELAND

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 1995年 / 164卷 / 01期

关键词：

D O I：

10.1007/BF02968109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interethnic differences in drug responsiveness may in part be accounted for by differences in drug disposition. We investigated the reversible binding interaction by equlibrium dialysis between a representative acidic (warfarin) and basic (lignocaine) drug and drug binding proteins in 20 healthy age and sex matched Iranian and Irish (Caucasian) subjects. The unbound fraction of warfarin and its major binding protein albumin, were similar in the two groups. In contrast unbound lignocaine was higher in Iranian subjects (49.6 +/- 6.96 vs 37.7 +/- 51%, mean +/- SD, p < 0.05) and this was associated with lower plasma concentrations of alpha(1) acid glycoprotein (AAG, 48.8 +/- 10 vs. 60.5 +/- 8 mg/dl p < 0.01) Such alterations may result in differences in drug responsiveness in addition to predictable pharmacokinetic consequences. Protein binding should be included in comparative studies of drugs in subjects of different races.

引用

页码：26 / 27

页数：2

共 13 条

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