FACILITATORY ROLE OF NEUROPEPTIDE-Y ON THE ONSET OF PUBERTY - EFFECT OF IMMUNONEUTRALIZATION OF NEUROPEPTIDE-Y ON THE RELEASE OF LUTEINIZING-HORMONE AND LUTEINIZING-HORMONE-RELEASING HORMONE

被引:39
作者
MINAMI, S
FRAUTSCHY, SA
PLOTSKY, PM
SUTTON, SW
SARKAR, DK
机构
[1] WASHINGTON STATE UNIV,DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL,PULLMAN,WA 99164
[2] SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL,LA JOLLA,CA 92037
关键词
Female rat; Luteinizing hormone; Luteinizing hormone-releasing hormone; Neuropeptide Y; Preovulatory luteinizing hormone surge; Puberty;
D O I
10.1159/000125548
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To examine the role of neuropeptide Y (NPY) in the first luteinizing hormone (LH) surge of puberty, the effect of passive immunoneutralization of NPY with antiserum against NPY (anti-NPY) injected centrally (third ventricle) or peripherally (jugular vein) was studied in pubertal female rats on the day of first proestrus. Both peripheral and central anti-NPY administration reduced the magnitude of the LH surge during the afternoon of first proestrus; however, the central route of administration appeared to be most effective. Centrally administered anti-NPY also reduced the magnitude of proestrous LH-releasing hormone (LHRH) release into pituitary portal blood in these rats. These results suggest that endogenous NPY plays a facilitatory role in the generation of the LHRH surge necessary for preovulatory gonadotropin release and puberty. © 1990 S. Karger AG, Basel.
引用
收藏
页码:112 / 115
页数:4
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