CYTOLOGIC DIAGNOSIS OF HUMAN PAPILLOMAVIRUS INFECTION - SPINDLED NUCLEI

被引：6

作者：

SHROYER, KR

HOSEY, J

SWANSON, LE

WOODARD, WD

FENNELL, RH

机构：

[1] Departments of Pathology and Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1990年 / 6卷 / 03期

关键词：

Cervical condyloma; Cytology; Electron microsco; Human papillomavirus;

D O I：

10.1002/dc.2840060307

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The classic cytologic criteria, koilocytotic atypia and dyskera‐tocytosis, fail to identify most cases with colposcopic and histologic evidence of cervical condylomata. The purpose of this study was to identify a novel cytologic diagnostic criterion, spindled nuclei, to predict the presence of human papillomavirus (HPV) infection of the cervical epithelium. Review of the hospital records of 100 consecutive cases with spindled nuclei on Papanicolaou smear identifed 36 patients in whom a colposcopic examination and/or cervical biopsy had been performed between January 1, 1988, and March 31, 1989. Ninety‐seven percent of these 36 cases were positive by colposcopy and 89% of the cases were positive by cervical biopsy for changes of condyloma or intraepithelial neoplasia. HPV DNA hybridization in situ was positive in 16 of 36 patients, and the probe for types 31/33/35 most often stained histologic sections showing condylomatous change without concurrent dysplasia. Electron microscopy of spindled nuclei showed evidence of HPV‐type viral particles in the five cases examined. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：178 / 183

页数：6

共 20 条

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