CUTANEOUS REACTIONS TO SUBSTANCE-P AND HISTAMINE IN ATOPIC-DERMATITIS

被引：41

作者：

COULSON, IH

HOLDEN, CA

机构：

[1] Skin Laboratory, St Helier Hospital, Carshalton, Surrey SM5 1AA, Wrythe Lane

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 03期

关键词：

D O I：

10.1111/j.1365-2133.1990.tb08282.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The flare and weal reactions to intradermal injections of histamine and the peptide substance P were measured in a group of patients with atopic dermatitis and compared to reactions in a non-atopic control group. There was no significant difference in the flare areas between the controls and atopics with either reagent. The weal volumes after injection of substance P and histamine were significantly larger in the atopic group. As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopics may be entirely due to the exaggerated atopic weal reaction to histamine.

引用

页码：343 / 349

页数：7

共 19 条

[1] ACTIONS OF LOCALLY ADMINISTERED ADRENOCEPTOR AGONISTS ON HISTAMINE-INDUCED CUTANEOUS RESPONSES IN ATOPIC ECZEMA [J].