IDENTIFICATION AND INITIAL CHARACTERIZATION OF A 4TH LEADER EXON AND PROMOTER OF THE HUMAN IGF-II GENE

被引：86

作者：

HOLTHUIZEN, P ^{[1
]}

VANDERLEE, FM ^{[1
]}

IKEJIRI, K ^{[1
]}

YAMAMOTO, M ^{[1
]}

SUSSENBACH, JS ^{[1
]}

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT BIOCHEM,FUKUOKA 812,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1087卷 / 03期

关键词：

Gene structure; Human gene; IGF-II; Insulin-like growth factor; Promoter;

D O I：

10.1016/0167-4781(90)90010-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription of the human insulin-like growth factor II (IGF-II) gene is regulated by activation of multiple promoters which act in a tissue-specific and development-dependent manner. Previously, we have identified three different promoters, one of which is active in adult liver tissue only, whereas the other two are active in many fetal tissues and adult non-hepatic tissues. Here we report the identification of a fourth leader exon of the human IGF-II gene indicating the presence of a fourth promoter. Transcription from this promoter yields a 5.0 kb IGF-II mRNA species, which is detected in fetal liver and leiomyosarcoma tissue. © 1990.

引用

页码：341 / 343

页数：3

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