AVIDITY OF SPECIFIC IGG ANTIBODY AS A MARKER OF RECENT AND OLD TOXOPLASMA INFECTIONS

被引：27

作者：

CAMARGO, ME ^{[1
]}

DASILVA, SM ^{[1
]}

LESER, PG ^{[1
]}

GRANATO, CH ^{[1
]}

机构：

[1] BIOLAB DIAGNOST SA,SAO PAULO,BRAZIL

来源：

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 1991年 / 33卷 / 03期

关键词：

D O I：

10.1590/S0036-46651991000300008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

For serologically characterizing a recent primary toxoplasma infection, the low avidity of IgG specific antibodies was studied. Avidity was evaluated as the decrease of IgG antibody titers in ELISA after treating plates with 6 M urea, as a dissociating solution of low avidity antigen-antibody complexes. Sixty nine serum samples were studied, presenting characteristic patterns of recent, transitional or chronic toxoplasmosis. Serological patterns were determined according to results of IgG and IgM immunofluorescence, IgM-capture, and hemagglutination tests. Twenty three serum samples from each of the referred patterns I,II and III were titrated. For chronic toxoplasmosis infections, which presented a serological pattern III, observed decrease of titers was 3% +/- 3%. For pattern I recent toxoplasmosis sera it was 34% +/- 12%, and for transition pattern II, 12% +/- 9%. Thus, a low avidity of IgG specific antibodies can be applicable for the diagnosis of a recent toxoplasmosis infection.

引用

页码：213 / 218

页数：6

共 9 条

[1]

Camargo M E, 1976, Rev Inst Med Trop Sao Paulo, V18, P227

[2]

CAMARGO ME, 1983, REV I MED TROP, V25, P201

[3] IMMUNOENZYMATIC ASSAY OF ANTI-DIPHTHERIC TOXIN ANTIBODIES IN HUMAN-SERUM [J].