INTERLEUKIN-1-INDUCED INTERLEUKIN-6 IS REQUIRED FOR THE INHIBITION OF PROTEOGLYCAN SYNTHESIS BY INTERLEUKIN-1 IN HUMAN ARTICULAR-CARTILAGE

被引：127

作者：

NIETFELD, JJ

WILBRINK, B

HELLE, M

VANROY, JLAM

DENOTTER, W

SWAAK, AJG

HUBERBRUNING, O

机构：

[1] DR DANIEL DEN HOED HOSP,DEPT RHEUMATOL,ROTTERDAM,NETHERLANDS

[2] STATE UNIV UTRECHT HOSP,DEPT EXPTL PATHOL,3511 GV UTRECHT,NETHERLANDS

[3] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 11期

关键词：

D O I：

10.1002/art.1780331113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cartilage from normal controls, patients with osteoarthritis, and patients with rheumatoid arthritis produced no interleukin‐6 (IL‐6) in culture. However, IL‐1 induced massive production of IL‐6 (up to 135 ng/ml) in cartilage from all 3 sources, in a dose‐dependent manner (in some cases, a peak value was reached). The levels of induced IL‐6 were similar to those found in rheumatoid arthritis synovial fluid. At IL‐1 concentrations that induced almost complete inhibition of proteoglycan (PG) synthesis, IL‐6 production could still be increased considerably. Exogenous IL‐6 inhibited PG synthesis by up to 25%. IL‐1‐induced inhibition of PG synthesis was reversed by antibodies against recombinant human IL‐6. These results suggest that IL‐6 is required for the IL‐1‐induced inhibition of PG synthesis. Copyright © 1990 American College of Rheumatology

引用

页码：1695 / 1701

页数：7

共 27 条

[1] INDEPENDENT EFFECTS OF INTERLEUKIN-1 ON PROTEOGLYCAN BREAKDOWN, PROTEOGLYCAN SYNTHESIS, AND PROSTAGLANDIN-E2 RELEASE FROM CARTILAGE IN ORGAN-CULTURE [J].