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CENTRALLY ACTIVE 5-HT RECEPTOR AGONISTS AND ANTAGONISTS

被引：115
作者：
MIDDLEMISS, DN
TRICKLEBANK, MD
机构：
[1] Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre Terlings Park, Harlow, Essex CM20 2QR, Eastwick Road
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1992年 / 16卷 / 01期
关键词：
5-HT1A-RECEPTORS; 5-HT1B-RECEPTORS; 5-HT1C-RECEPTORS; 5-HT1D-RECEPTORS; 5-HT2-RECEPTORS; 5-HT3-RECEPTORS; ANTAGONISTS; AGONISTS;
D O I：
10.1016/S0149-7634(05)80054-5
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Eleven subtypes of central 5-HT receptor have so far been postulated, four of which have been cloned (5-HT1C 5-HT1C, 5-HT1D and 5-HT2) and a fifth (the 5-HT3 receptor) purified. The present review discusses the agonists and antagonists which act at these subtypes with respect to their degree of selectivity and in vivo potency. Selective agonists exist for the 5-HT1A, 5-HT1B and 5-HT3 receptors and selective antagonists for the 5-HT2 and 5-HT3 receptors.
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页码：75 / 82
页数：8
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