PYRROLOSTATIN, A NOVEL LIPID-PEROXIDATION INHIBITOR FROM STREPTOMYCES-CHRESTOMYCETICUS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

被引：38

作者：

KATO, S

SHINDO, K

KAWAI, H

ODAGAWA, A

MATSUOKA, M

MOCHIZUKI, J

机构：

[1] Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma 370-12, Takasaki

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 06期

关键词：

D O I：

10.7164/antibiotics.46.892

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.

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页码：892 / 899

页数：8

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