BENZANNULATION OF AROMATIC HETEROCYCLES - A REGIOCONTROLLED METHOD FOR CONSTRUCTION OF SUBSTITUTED BENZOFURANS AND DIBENZOFURANS AND BENZOTHIOPHENES AND DIBENZOTHIOPHENES

被引：62

作者：

LIEBESKIND, LS

WANG, JY

机构：

[1] Department of Chemistry, Emory University, Atlanta

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 13期

关键词：

D O I：

10.1021/jo00065a017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Chloro-2,3-disubstituted-2-cyclobutenones undergo palladium-catalyzed cross-coupling with oxygen and sulfur heteroaryl tin reagents, and upon thermolysis at 100-degrees-C, good to high yields of substituted benzannulated heteroaromatics are formed. Relying on the control inherent in the construction of 4-chloro-2,3-disubstituted-2-cyclobutenones, regioisomeric substituted heteroaromatics are easily prepared.

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页码：3550 / 3556

页数：7

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