CONTROL OF GASTRIC-ACID HYPERSECRETION IN THE MANAGEMENT OF PATIENTS WITH ZOLLINGER-ELLISON SYNDROME

被引:77
作者
METZ, DC [1 ]
PISEGNA, JR [1 ]
FISHBEYN, VA [1 ]
BENYA, RV [1 ]
JENSEN, RT [1 ]
机构
[1] NIDDK,DIGEST DIS BRANCH,BETHESDA,MD
关键词
D O I
10.1007/BF01655106
中图分类号
R61 [外科手术学];
学科分类号
摘要
During the last 5 years important advances have occurred in the control of gastric acid hypersecretion in Zollinger-Ellison syndrome (ZES). The increased availability of potent gastric acid antisecretory agents such as histamine H-2-receptor antagonists and more recently the H+K+-ATPase inhibitors such as omeprazole and lansoprazole have made it possible to medically control acid secretion in all patients. Increased understanding of the variation in antisecretory drug dosage between individual patients has led to identification of criteria to ensure effective antisecretory control and to the recognition of subgroups of patients who require special monitoring. Effective regimens for parenteral antisecretory control during surgery have been established. The importance of parathyroidectomy in patients with multiple endocrine neoplasia type I with ZES and the possible usefulness of highly selective vagotomy have been investigated. We review here the new data that led to increased understanding in each of these areas from our studies and studies by others.
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页码:468 / 480
页数:13
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