PROTECTION OF GERBILS FROM AMEBIC LIVER-ABSCESS BY IMMUNIZATION WITH A RECOMBINANT PROTEIN-DERIVED FROM THE 170-KILODALTON SURFACE ADHESIN OF ENTAMOEBA-HISTOLYTICA

被引:57
作者
ZHANG, TH
STANLEY, SL
机构
[1] WASHINGTON UNIV, SCH MED, DEPT MED, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA
关键词
D O I
10.1128/IAI.62.6.2605-2608.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
The protozoan parasite Entamoeba histolytica causes extensive morbidity and mortality worldwide through intestinal infection and amebic liver abscess. Here we show that vaccination of gerbils, a standard model for amebic liver abscess,,vith recombinant proteins derived from the 170-kDa galactose-binding adhesin of E. histolytica and the serine-rich E. histolytica protein or a combination of the two recombinant antigens provides excellent protection against subsequent hepatic challenge with virulent E. histolytica trophozoites.
引用
收藏
页码:2605 / 2608
页数:4
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