ENZYME INHIBITORS .13. SYNTHESIS OF AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF ADENOSINE DEAMINASE

被引：38

作者：

SCHAEFFE.HJ

ODIN, E

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1966年 / 9卷 / 04期

关键词：

D O I：

10.1021/jm00322a030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：576 / &

相关论文

共 20 条

[1] NON-CLASSICAL ANTIMETABOLITES .6. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR [J].

BAKER, BR ;

LEE, WW ;

TONG, E .

JOURNAL OF THEORETICAL BIOLOGY, 1962, 3 (03) :459-&

[2] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[3] ANALOGS OF TETRAHYDROFOLIC ACID .21. SYNTHESIS OF 6-BROMOMETHYL-5-(P-CHLOROPHENYL)-2,4-DIAMINOPYRIMIDINE AND ITS EVALUATION AS A DIHYDROFOLIC REDUCTASE INHIBITOR [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (01) :21-&

[4] NON-CLASSICAL ANTIMETABOLITES .8. BRIDGE PRINCIPLE OF SPECIFICITY WITH EXO-ALKYLATING IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

BIOCHEMICAL PHARMACOLOGY, 1962, 11 (DEC) :1155-&

[5] A STUDY OF COMPARATIVE CHEMICAL AND BIOLOGICAL ACTIVITIES OF ALKYLATING AGENTS [J].

BARDOS, TJ ;

DATTAGUP.N ;

HEBBORN, P ;

TRIGGLE, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) :167-&

[6] USE OF GAMMA-(4-NITROBENZYL)PYRIDINE AS ANALYTICAL REAGENT FOR ETHYLENIMINES AND ALKYLATING AGENTS [J].

EPSTEIN, J ;

ROSENTHAL, RW ;

ESS, RJ .

ANALYTICAL CHEMISTRY, 1955, 27 (09) :1435-1439

[7] STUDIES ON POLYNUCLEOTIDES .1. A NEW AND GENERAL METHOD FOR THE CHEMICAL SYNTHESIS OF THE C5'-C3' INTERNUCLEOTIDIC LINKAGE - SYNTHESES OF DEOXYRIBO-DINUCLEOTIDES [J].

GILHAM, PT ;

KHORANA, HG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (23) :6212-6222

[8] SPECIFIC ADENOSINE DEAMINASE FROM INTESTINE [J].

KAPLAN, NO .

METHODS IN ENZYMOLOGY, 1955, 2 :473-475

[9] MODIFICATION OF A METHIONINE RESIDUE NEAR ACTIVE SITE OF CHYMOTRYPSIN [J].

LAWSON, WB ;

SCHRAMM, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (10) :2017-&

[10] MODIFICATION OF A METHIONINE RESIDUE NEAR ACTIVE SITE OF CHYMOTRYPSIN BY P-NITROPHENYL BROMOACETYL-ALPHA-AMINOISOBUTYRATE [J].

LAWSON, WB ;

SCHRAMM, HJ .

BIOCHEMISTRY, 1965, 4 (03) :377-&